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Composite adeno-endocrine carcinoma of the gallbladder with long-term survival.
[carcinoma of the gallbladder]
Primary
endocrine
cell
tumors
in
the
gallbladder
are
uncommon
,
and
the
coexistence
of
an
endocrine
cell
tumor
and
adenocarcinoma
,
squamous
cell
carcinoma
,
and
sarcomatoid
components
is
extremely
rare
.
A
rare
case
of
adeno-endocrine
cell
carcinoma
of
the
gallbladder
in
an
81
-
year
-old
woman
is
reported
.
Abdominal
ultrasonography
(
US
)
revealed
a
hypo-echoic
,
solid
tumor
,
2
.
0
cm
×
1
.
8
cm
in
size
,
at
the
fundus
of
the
gallbladder
.
On
computed
tomography
(
CT
)
,
the
tumor
was
well-enhanced
,
well-demarcated
,
and
homogeneous
.
The
tumor
,
which
was
papillary
,
protruded
into
the
gallbladder
with
no
direct
invasion
to
the
liver
.
The
tumor
was
diagnosed
as
gallbladder
carcinoma
;
its
depth
appeared
not
to
pass
the
subserosa
layer
.
A
cholecystectomy
and
hepatic
bed
resection
with
regional
lymph
node
dissection
were
performed
.
Histologically
,
the
tumor
consisted
of
several
components
,
including
well
to
poorly
differentiated
papillary
and
tubular
adenocarcinoma
with
squamous
and
sarcomatoid
differentiations
,
and
endocrine
cell
carcinoma
.
Histochemical
studies
of
these
tumor
cells
were
positive
for
chromogranin
A
,
synaptophysin
,
and
cluster
of
differentiation
56
(
CD
5
6
)
.
The
lymph
node
consisted
of
metastatic
adeno-endocrine
carcinoma
.
The
patient
survived
and
has
remained
disease-free
for
4
years
without
adjuvant
chemotherapy
.
Adeno-endocrine
cell
carcinoma
of
the
gallbladder
generally
has
a
poor
prognosis
.
The
present
case
suggests
that
adeno-endocrine
cell
carcinoma
with
various
components
may
be
derived
from
a
common
precursor
cell
.
This
observation
would
require
further
investigation
.
Diseases
Validation
Diseases presenting
"and sarcomatoid components is extremely rare"
symptom
carcinoma of the gallbladder
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