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Composite adeno-endocrine carcinoma of the gallbladder with long-term survival.
[carcinoma of the gallbladder]
Primary
endocrine
cell
tumors
in
the
gallbladder
are
uncommon
,
and
the
coexistence
of
an
endocrine
cell
tumor
and
adenocarcinoma
,
squamous
cell
carcinoma
,
and
sarcomatoid
components
is
extremely
rare
.
A
rare
case
of
adeno-endocrine
cell
carcinoma
of
the
gallbladder
in
an
81
-
year
-old
woman
is
reported
.
Abdominal
ultrasonography
(
US
)
revealed
a
hypo-echoic
,
solid
tumor
,
2
.
0
cm
×
1
.
8
cm
in
size
,
at
the
fundus
of
the
gallbladder
.
On
computed
tomography
(
CT
)
,
the
tumor
was
well-enhanced
,
well-demarcated
,
and
homogeneous
.
The
tumor
,
which
was
papillary
,
protruded
into
the
gallbladder
with
no
direct
invasion
to
the
liver
.
The
tumor
was
diagnosed
as
gallbladder
carcinoma
;
its
depth
appeared
not
to
pass
the
subserosa
layer
.
A
cholecystectomy
and
hepatic
bed
resection
with
regional
lymph
node
dissection
were
performed
.
Histologically
,
the
tumor
consisted
of
several
components
,
including
well
to
poorly
differentiated
papillary
and
tubular
adenocarcinoma
with
squamous
and
sarcomatoid
differentiations
,
and
endocrine
cell
carcinoma
.
Histochemical
studies
of
these
tumor
cells
were
positive
for
chromogranin
A
,
synaptophysin
,
and
cluster
of
differentiation
56
(
CD
5
6
)
.
The
lymph
node
consisted
of
metastatic
adeno-endocrine
carcinoma
.
The
patient
survived
and
has
remained
disease-free
for
4
years
without
adjuvant
chemotherapy
.
Adeno-endocrine
cell
carcinoma
of
the
gallbladder
generally
has
a
poor
prognosis
.
The
present
case
suggests
that
adeno-endocrine
cell
carcinoma
with
various
components
may
be
derived
from
a
common
precursor
cell
.
This
observation
would
require
further
investigation
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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