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Imprint cytological feature of large cell neuroendocrine carcinoma of the gallbladder: a case report.
[carcinoma of the gallbladder]
Large
cell
neuroendocrine
carcinoma
(
LCNEC
)
is
a
rare
poorly
differentiated
carcinoma
with
neuroendocrine
differentiation
showing
aggressive
clinical
behavior
.
We
herein
report
a
case
of
gallbladder
LCNEC
,
which
was
difficult
to
differentiate
from
poorly
differentiated
adenocarcinoma
.
An
imprint
cytology
was
very
useful
for
the
final
diagnosis
in
this
case
.
A
56
-
year
-old
male
with
left
exophthalmos
was
admitted
to
the
hospital
.
Radiological
examinations
revealed
the
presence
of
a
left
gallbladder
tumor
with
orbital
metastasis
.
The
histological
diagnosis
was
poorly
differentiated
adenocarcinoma
,
and
intensive
chemoradiotherapy
was
administered
.
Unfortunately
,
the
patient
died
of
extensive
metastases
36
months
after
the
initial
onset
of
symptoms
.
An
autopsy
revealed
a
tumor
mass
in
the
gallbladder
associated
with
multiple
liver
and
peritoneal
metastases
.
Imprint
cytology
of
the
main
tumor
revealed
cytological
features
of
LCNEC
,
and
additional
histological
examinations
confirmed
this
diagnosis
.
Although
performing
a
histological
examination
is
important
for
making
a
final
diagnosis
,
imprint
cytology
is
powerful
tool
for
differential
diagnosis
of
LCNEC
,
especially
in
patients
with
carcinoma
with
poor
differentiation
.