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[Prevalence and sequence of metaplasia-dysplasia-carcinoma of the gallbladder. A single centre retrospective study].
[carcinoma of the gallbladder]
We
report
the
frequency
and
age
of
metaplasia
,
dysplasia
and
carcinoma
of
the
gallbladder
,
and
seek
to
establish
a
sequence
of
progression
of
these
,
since
several
studies
suggest
that
this
is
the
carcinogenesis
pathway
.
Descriptive
retrospective
cross-sectional
study
over
a
period
of
4
years
,
with
an
analytical
component
of
1
,
514
patients
with
cholelithiasis
,
in
whom
cholecystectomy
were
performed
.
The
mean
age
of
the
sample
was
46
years
and
72
%
of
patients
were
female
.
The
prevalence
(
and
mean
age
)
of
pyloric
metaplasia
,
intestinal
metaplasia
,
dysplasia
and
carcinoma
was
22
.
6
(
47
)
,
2
.
1
(
46
)
,
0
.
2
(
54
)
and
0
.
6
%
(
63
years
)
,
respectively
.
There
was
a
significant
association
between
intestinal
and
pyloric
metaplasia
(
P
<
.
001
,
chi
(
2
)
)
and
between
dysplasia
and
carcinoma
(
P
<
.
005
,
Yates
)
,
but
not
between
metaplasia
and
dysplasia
.
Improved
studies
should
be
conducted
for
the
correct
interpretation
of
the
pathogenesis
of
gallbladder
cancer
.
Diseases
Validation
Diseases presenting
"cholelithiasis"
symptom
achondroplasia
alpha-thalassemia
benign recurrent intrahepatic cholestasis
carcinoma of the gallbladder
cholangiocarcinoma
erythropoietic protoporphyria
This symptom has already been validated