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[Prevalence and sequence of metaplasia-dysplasia-carcinoma of the gallbladder. A single centre retrospective study].
[carcinoma of the gallbladder]
We
report
the
frequency
and
age
of
metaplasia
,
dysplasia
and
carcinoma
of
the
gallbladder
,
and
seek
to
establish
a
sequence
of
progression
of
these
,
since
several
studies
suggest
that
this
is
the
carcinogenesis
pathway
.
Descriptive
retrospective
cross-sectional
study
over
a
period
of
4
years
,
with
an
analytical
component
of
1
,
514
patients
with
cholelithiasis
,
in
whom
cholecystectomy
were
performed
.
The
mean
age
of
the
sample
was
46
years
and
72
%
of
patients
were
female
.
The
prevalence
(
and
mean
age
)
of
pyloric
metaplasia
,
intestinal
metaplasia
,
dysplasia
and
carcinoma
was
22
.
6
(
47
)
,
2
.
1
(
46
)
,
0
.
2
(
54
)
and
0
.
6
%
(
63
years
)
,
respectively
.
There
was
a
significant
association
between
intestinal
and
pyloric
metaplasia
(
P
<
.
001
,
chi
(
2
)
)
and
between
dysplasia
and
carcinoma
(
P
<
.
005
,
Yates
)
,
but
not
between
metaplasia
and
dysplasia
.
Improved
studies
should
be
conducted
for
the
correct
interpretation
of
the
pathogenesis
of
gallbladder
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
