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Clinicopathologic analysis of undifferentiated carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Undifferentiated
carcinoma
(
UC
)
of
the
gallbladder
(
GB
)
is
a
rare
malignant
neoplasm
and
there
have
only
been
sparse
case
reports
without
precise
description
.
We
analyzed
eight
cases
of
UC
of
GB
and
compared
with
gallbladder
carcinoma
(
GBC
)
in
the
aspects
of
clinicopathologic
characteristics
and
prognosis
.
We
found
eight
UC
cases
out
of
238
surgically
resected
GBCs
.
Patients
with
stage
-matched
GBC
were
selected
(
1
:
4
)
for
comparative
analysis
of
the
clinicopathologic
features
and
survival
of
UC
.
H
istologically
,
UC
cases
were
composed
of
four
sarcomatoid
,
two
pleomorphic
,
one
small
cell
,
and
one
osteoclast-like
giant
cell
types
.
There
was
no
difference
between
UC
and
ordinary
GBC
in
clinicopathologic
parameters
,
except
for
tumor
size
.
It
was
significantly
larger
in
UC
(
median
;
5
.
0
cm
,
ranging
1
.
3
-
10
.
0
cm
)
compared
to
GBC
(
median
;
3
.
0
cm
,
ranging
1
.
5
-
9
.
0
cm
,
P
=
0
.
01
)
.
UC
presented
frequent
intraluminal
polypoid
mass
(
87
.
5
%
:
7
/
8
)
.
UC
showed
significantly
poor
overall
survival
rate
(
37
.
5
%
,
37
.
5
%
and
18
.
8
%
at
1
,
3
,
and
5
years
)
,
than
GBC
(
84
.
4
%
,
65
.
6
%
and
52
.
1
%
,
respectively
)
(
P
=
0
.
005
)
.
Pathologic
findings
of
UC
were
an
independent
prognostic
factor
for
poor
survival
in
GBC
(
HR
7
.
242
,
95
%
confidence
interval
:
1
.
799
-
29
.
147
)
.
Undifferentiated
carcinoma
of
the
gallbladder
was
a
rare
highly
malignant
neoplasm
and
frequently
presented
a
large
intraluminal
polypoid
tumor
.
It
showed
a
significantly
larger
tumor
size
and
poorer
survival
than
GBC
.
Diseases
Validation
Diseases presenting
"independent prognostic factor"
symptom
carcinoma of the gallbladder
cholangiocarcinoma
cutaneous mastocytosis
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
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