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Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Cancer
of
the
gallbladder
is
a
relatively
rare
neoplasm
with
a
poor
prognosis
.
The
exact
mechanisms
of
its
genesis
are
not
known
and
very
little
information
is
available
on
molecular
events
leading
to
labeling
this
as
an
orphan
cancer
.
In
this
prospective
case
control
study
we
evaluated
the
expression
of
p
16
,
pRb
and
cyclin
D
1
by
immunohistochemistry
to
study
the
G
1
-
S
cell-cycle
check
point
and
its
possible
role
in
gallbladder
carcinogenesis
.
A
total
of
25
patients
with
gallbladder
carcinoma
(
group
I
)
,
25
with
cholelithiasis
(
group
II
)
and
10
normal
controls
.
were
enrolled
.
Cyclin
D
1
expression
was
seen
in
10
(
40
%
)
patients
each
with
carcinoma
and
cholelithiasis
while
only
in
2
(
20
%
)
of
the
normal
gallbladders
but
differences
were
not
statistically
significant
(
p
value
=
0
.
488
)
.
p
16
was
expressed
in
12
%
patients
of
carcinoma
of
the
gallbladder
and
28
%
of
cholelithiasis
,
however
this
difference
was
not
statistically
significant
(
p
value
=
0
.
095
)
.
Retinoblastoma
protein
was
found
to
be
expressed
in
50
%
of
normal
gallbladders
and
6
(
24
%
)
of
carcinoma
and
8
(
32
%
)
of
gallstones
.
The
present
study
failed
to
demonstrate
any
conclusive
role
of
cyclin
D
1
/
RB
/
p
16
pathway
in
carcinoma
of
the
gallbladder
.
The
positive
relation
observed
between
tumor
metastasis
and
cyclinD
1
expression
and
p
16
with
nodal
metastasis
suggested
that
higher
cyclin
D
1
/
p
16
expression
may
act
as
a
predictive
biomarker
for
aggressive
behavior
of
gallbladder
malignancies
.
Diseases
Validation
Diseases presenting
"cancer of the gallbladder"
symptom
carcinoma of the gallbladder
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