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Heavy and trace metals in carcinoma of the gallbladder.
[carcinoma of the gallbladder]
Carcinoma
of
the
gallbladder
is
the
commonest
malignancy
of
the
biliary
tract
in
northern
India
The
etiologic
relation
of
specific
metals
(
heavy
and
trace
)
and
their
compounds
to
neoplasia
has
been
a
topic
of
investigation
for
some
time
but
not
adequately
described
for
carcinoma
of
the
gallbladder
.
The
aim
of
the
present
study
was
to
evaluate
the
relation
of
heavy
and
trace
metals
to
this
malignancy
.
The
levels
of
selenium
,
zinc
,
copper
,
manganese
,
cadmium
,
chromium
,
lead
,
and
nickel
were
estimated
in
serum
,
bile
,
gallstones
,
and
gallbladder
tissue
using
atomic
absorption
spectrophotometry
.
The
tests
were
carried
out
in
30
patients
with
gallbladder
cancer
and
30
sex-matched
patients
with
cholelithiasis
.
Selenium
and
zinc
levels
were
significantly
reduced
(
p
<
0
.
001
)
and
copper
concentration
was
found
to
be
significantly
higher
(
p
<
0
.
001
)
in
serum
,
bile
,
and
gallbladder
tissue
from
patients
with
carcinoma
of
the
gallbladder
.
Lead
,
cadmium
,
chromium
,
and
nickel
levels
were
elevated
in
serum
and
bile
in
patients
with
carcinoma
of
the
gallbladder
.
The
present
study
demonstrated
a
significant
decrease
in
serum
,
biliary
,
and
tissue
levels
of
selenium
and
zinc
but
increased
copper
,
lead
,
cadmium
,
chromium
,
and
nickel
levels
in
patients
with
carcinoma
of
the
gallbladder
,
indicating
a
strong
relation
between
the
concentrations
of
these
metals
and
gallbladder
cancer
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
