The etiology of short stature affects the clinical outcome of lower limb lengthening using external fixation. A systematic review of 18 trials involving 547 patients.

[achondroplasia]

Distraction osteogenesis (DO ) has been used to gain height in short statured individuals . However , there have been no studies comparing the clinical outcome of limb lengthening based on the etiology of the short stature . We assessed whether different underlying diagnoses are associated with varied clinical outcomes in these patients .We performed a systematic review of the literature pertaining to lower limb lengthening using external fixation for short stature . Clinical outcomes including amount of lengthening , healing index (HI ), and complications based on the underlying diagnosis for the short stature were documented .18 clinical studies were included , with 547 patients who underwent 1 ,581 lower limb segment lengthening procedures . Mean follow-up was 4 .3 years . The average age at lengthening was less for individuals with achondroplasia /hypochondroplasia (A /H ) (14 .5 years ) than for those with Turner 's syndrome (TS ) (18 .2 years ) or with constitutional short stature (CSS ) (21 .7 years ). Mean height gained was greater in patients with A /H (9 .5 cm ) than in those with TS (7 .7 cm ) or CSS (6 .1 cm ) group . The HI was better in A /H (30 .8 days /cm ) and CSS (32 days /cm ) than in TS (45 .1 days /cm ). The reported complication rate per segment was lower for A /H (0 .68 ) and TS (0 .71 ) than for CSS (1 .06 ).Patients with A /H tolerated larger amounts of lengthening with fewer complications than those with other diagnoses .

Diseases
Validation

Diseases presenting "constitutional short stature" symptom

achondroplasia

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