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[Neuroendocrine gallbladder cancer treated with cisplatin plus irinotecan - a case report].
[carcinoma of the gallbladder]
A
52
-
year
-old
woman
was
referred
to
our
hospital
because
of
upper
abdominal
pain
.
A
computed
tomography
(
CT
)
scan
revealed
bulky
gallbladder
and
liver
tumors
.
We
reached
a
tentative
diagnosis
of
invasive
adenocarcinoma
of
the
gallbladder
and
performed
needle
biopsy
of
the
tumor
.
Biopsied
specimens
showed
the
proliferation
of
small
round
to
oval
cells
with
scanty
cytoplasm
and
high
rates
of
mitosis
.
Immunohistochemical
examination
showed
that
many
tumor
cells
were
positive
for
chromogranin
A
,
synaptophysin
,
and
CD
5
6
.
Our
final
diagnosis
was
neuroendocrine
carcinoma
of
the
gallbladder
with
multiple
liver
metastases
.
The
patient
received
cisplatin
plus
irinotecan
chemotherapy
.
Remarkable
shrinkage
was
observed
after
3
cycles
of
chemotherapy
,
and
a
good
response
continued
for
more
than
6
months
.
Gallbladder
cancer
patients
generally
have
a
poor
response
to
chemotherapy
,
so
we
should
be
aware
of
the
histopathological
diagnosis
of
the
cancer
before
starting
treatment
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated