Rare Diseases Symptoms Automatic Extraction

[Neuroendocrine gallbladder cancer treated with cisplatin plus irinotecan - a case report].

[carcinoma of the gallbladder]

A 52-year-old woman was referred to our hospital because of upper abdominal pain. A computed tomography(CT)scan revealed bulky gallbladder and liver tumors. We reached a tentative diagnosis of invasive adenocarcinoma of the gallbladder and performed needle biopsy of the tumor. Biopsied specimens showed the proliferation of small round to oval cells with scanty cytoplasm and high rates of mitosis. Immunohistochemical examination showed that many tumor cells were positive for chromogranin A, synaptophysin, and CD56. Our final diagnosis was neuroendocrine carcinoma of the gallbladder with multiple liver metastases. The patient received cisplatin plus irinotecan chemotherapy. Remarkable shrinkage was observed after 3 cycles of chemotherapy, and a good response continued for more than 6 months. Gallbladder cancer patients generally have a poor response to chemotherapy, so we should be aware of the histopathological diagnosis of the cancer before starting treatment.

Diseases presenting "cancer" symptom

  • achondroplasia
  • acute rheumatic fever
  • adrenal incidentaloma
  • alpha-thalassemia
  • benign recurrent intrahepatic cholestasis
  • cadasil
  • canavan disease
  • carcinoma of the gallbladder
  • cholangiocarcinoma
  • coats disease
  • congenital adrenal hyperplasia
  • congenital diaphragmatic hernia
  • cowden syndrome
  • cushing syndrome
  • cutaneous mastocytosis
  • dedifferentiated liposarcoma
  • dystrophic epidermolysis bullosa
  • epidermolysis bullosa simplex
  • erdheim-chester disease
  • erythropoietic protoporphyria
  • esophageal adenocarcinoma
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • familial hypocalciuric hypercalcemia
  • familial mediterranean fever
  • gm1 gangliosidosis
  • heparin-induced thrombocytopenia
  • hereditary cerebral hemorrhage with amyloidosis
  • hirschsprung disease
  • hodgkin lymphoma, classical
  • inclusion body myositis
  • junctional epidermolysis bullosa
  • kabuki syndrome
  • kallmann syndrome
  • kindler syndrome
  • lamellar ichthyosis
  • liposarcoma
  • locked-in syndrome
  • lymphangioleiomyomatosis
  • monosomy 21
  • neuralgic amyotrophy
  • oculocutaneous albinism
  • oligodontia
  • oral submucous fibrosis
  • papillon-lefèvre syndrome
  • pendred syndrome
  • pleomorphic liposarcoma
  • primary effusion lymphoma
  • proteus syndrome
  • pyomyositis
  • pyruvate dehydrogenase deficiency
  • severe combined immunodeficiency
  • sneddon syndrome
  • systemic capillary leak syndrome
  • triple a syndrome
  • von hippel-lindau disease
  • waldenström macroglobulinemia
  • well-differentiated liposarcoma
  • werner syndrome
  • wiskott-aldrich syndrome
  • wolf-hirschhorn syndrome
  • x-linked adrenoleukodystrophy

This symptom has already been validated