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[Neuroendocrine gallbladder cancer treated with cisplatin plus irinotecan - a case report].
[carcinoma of the gallbladder]
A
52
-
year
-old
woman
was
referred
to
our
hospital
because
of
upper
abdominal
pain
.
A
computed
tomography
(
CT
)
scan
revealed
bulky
gallbladder
and
liver
tumors
.
We
reached
a
tentative
diagnosis
of
invasive
adenocarcinoma
of
the
gallbladder
and
performed
needle
biopsy
of
the
tumor
.
Biopsied
specimens
showed
the
proliferation
of
small
round
to
oval
cells
with
scanty
cytoplasm
and
high
rates
of
mitosis
.
Immunohistochemical
examination
showed
that
many
tumor
cells
were
positive
for
chromogranin
A
,
synaptophysin
,
and
CD
5
6
.
Our
final
diagnosis
was
neuroendocrine
carcinoma
of
the
gallbladder
with
multiple
liver
metastases
.
The
patient
received
cisplatin
plus
irinotecan
chemotherapy
.
Remarkable
shrinkage
was
observed
after
3
cycles
of
chemotherapy
,
and
a
good
response
continued
for
more
than
6
months
.
Gallbladder
cancer
patients
generally
have
a
poor
response
to
chemotherapy
,
so
we
should
be
aware
of
the
histopathological
diagnosis
of
the
cancer
before
starting
treatment
.
