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Granulocyte-colony stimulating factor-producing gallbladder carcinoma.
[carcinoma of the gallbladder]
Abstract
A
78
-
year
-old
man
was
admitted
to
our
hospital
with
right
upper
abdominal
pain
and
fever
.
His
general
condition
was
poor
.
The
laboratory
data
showed
severe
inflammatory
reactions
.
Computed
tomography
revealed
an
irregular
tumor
in
the
gallbladder
.
(
18
)
F-
fluorodeoxy-glucose
positron
emission
tomography
(
FDG-PET
)
showed
high
uptake
by
the
tumor
,
with
diffuse
uptake
in
the
spine
.
Based
on
the
elevated
leukocyte
count
and
FDG-PET
findings
,
a
granulocyte-colony
stimulating
factor
(
G-CSF
)
-
producing
tumor
was
diagnosed
(
G-CSF
120
pg
/
mL
)
.
We
performed
cholecystectomy
with
central
bisegmentectomy
of
the
liver
,
lymph
node
dissection
and
right
hemicolectomy
.
Histologically
,
the
tumor
was
an
adenosquamous
cell
carcinoma
of
the
gallbladder
.
Immunohistochemical
staining
of
the
tumor
cells
was
positive
for
G-CSF
.
Postoperatively
,
the
general
condition
of
the
patient
was
improved
.
The
fever
subsided
,
the
leukocyte
count
and
serum
G-CSF
level
normalized
,
and
FDG-PET
showed
no
uptake
in
the
spine
postoperatively
.
The
patient
showed
no
signs
of
recurrence
at
27
months
after
undergoing
surgery
.
FDG-PET
is
a
useful
method
for
diagnosing
G-CSF-producing
gallbladder
carcinoma
.
Aggressive
curative
resection
for
G-CSF-producing
gallbladder
carcinoma
may
improve
patients
'
general
condition
and
prognosis
.
Diseases
Validation
Diseases presenting
"fever"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
alexander disease
allergic bronchopulmonary aspergillosis
canavan disease
carcinoma of the gallbladder
child syndrome
congenital toxoplasmosis
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial mediterranean fever
focal myositis
hodgkin lymphoma, classical
lamellar ichthyosis
legionellosis
locked-in syndrome
malignant atrophic papulosis
neonatal adrenoleukodystrophy
neuralgic amyotrophy
oculocutaneous albinism
papillon-lefèvre syndrome
pyomyositis
pyruvate dehydrogenase deficiency
scrub typhus
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
typhoid
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated