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[Roles of cyclooxygenase 2/2', 3'-cyclic nucleotide3' phosphohydrolase in the oligodendrocyte apoptosis in heroin-induced spongiform leucoencephalopathy].
[canavan disease]
To
investigate
the
regulation
of
cyclooxygenase
(
Cox
)
-
2
/
2
'
,
3
'
-
cyclic
nucleotide
3
'
phosphohydrolase
(
CNPase
)
on
the
oligodendrocyte
apoptosis
in
the
pathogenesis
of
the
heroin-induced
spongiform
leucoencephalopathy
(
HSLE
)
.
Samples
of
frontal
lobe
,
cerebellum
,
and
corpus
callosum
were
obtained
from
the
brains
during
autopsy
of
4
HSLE
patients
and
5
patients
who
died
of
diseases
other
than
cerebral
diseases
(
controls
)
and
underwent
light
microscopy
and
electron
microscopy
.
Immunocytochemistry
was
carried
out
to
detect
the
expression
of
myelin
basic
protein
(
MBP
)
,
caspase-
3
,
COX
-
2
,
and
CNPase
protein
.
Apoptosis
was
examined
by
TUNEL
staining
.
Widespread
demyelination
was
seen
in
the
white
matter
of
the
frontal
lobe
,
cerebellum
,
and
corpus
callosum
of
the
HSLE
cases
,
most
severely
in
cerebellum
.
In
he
HSLE
group
,
the
levels
of
caspase-
3
and
COX
-
2
expression
were
significantly
higher
,
and
the
level
of
CNPase
was
significantly
lower
than
those
of
the
control
group
(
all
P
<
0
.
05
)
.
Widespread
demyelination
in
the
white
matter
is
a
prevailing
pathological
change
of
HSLE
.
Oligodendrocyte
apoptosis
is
one
of
the
causes
of
HSLE
.
The
upregulation
of
COX
-
2
and
downregulation
of
CNPase
may
contribute
to
the
pathogenesis
.
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Validation
Diseases presenting
"change of hsle"
symptom
canavan disease
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