Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Advanced intimal hyperplasia without luminal narrowing of leptomeningeal arteries in CADASIL.
[cadasil]
Leptomeningeal
artery
abnormalities
in
Cerebral
Autosomal-
Dominant
Arteriopathy
with
Subcortical
Infarcts
and
Leukoencephalopathy
(
CADASIL
)
have
not
been
extensively
characterized
.
We
quantified
substructure
and
diameter
of
leptomeningeal
arteries
in
CADASIL
compared
with
age-matched
controls
and
the
very
old
;
in
addition
,
we
characterized
intimal
thickening
in
CADASIL
using
immunohistochemistry
.
Frontal
and
temporal
cortex
of
6
genetically
proven
CADASIL
brains
(
average
age
,
66
years
)
,
6
controls
without
symptoms
of
cerebrovascular
disease
,
and
6
very
old
brains
(
average
age
,
89
years
)
were
examined
for
leptomeningeal
artery
intimal
,
medial
,
and
adventitial
thickness
;
inner
diameter
;
and
sclerotic
index
and
for
smooth
muscle
markers
.
T
he
intima
of
CADASIL
arteries
was
thickened
5
-
fold
compared
with
controls
and
the
very
aged
(
P
<
0
.
0001
)
.
Medial
thickness
was
lower
in
CADASIL
compared
with
controls
and
the
very
old
(
P
<
0
.
01
)
.
The
adventitia
was
not
significantly
increased
in
CADASIL
compared
with
age-matched
controls
.
Arterial
diameters
were
not
smaller
in
CADASIL
compared
with
controls
.
Sclerotic
index
was
significantly
increased
in
CADASIL
compared
with
other
groups
(
P
<
0
.
00001
)
.
Intimal
cells
in
CADASIL
expressed
smooth
muscle
actin
,
S
100
A
4
,
and
vimentin
but
not
desmin
.
Principle
changes
of
leptomeningeal
arteries
in
CADASIL
include
intimal
thickening
and
medial
thinning
,
but
not
luminal
narrowing
.
Smooth
muscle
-like
cells
participate
in
neointimal
thickening
of
CADASIL
arteries
.
Diseases
Validation
Diseases presenting
"s100a4"
symptom
cadasil
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom