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Headache among CADASIL patients with R544C mutation: prevalence, characteristics, and associations.
[cadasil]
There
are
variations
of
migraine
prevalence
in
cerebral
autosomal
dominant
arteriopathy
with
subcortical
infarcts
and
leukoencephalopathy
(
CADASIL
)
among
different
regions
of
the
world
.
Previous
studies
on
Asian
CADASIL
patients
have
not
provided
detailed
descriptions
of
the
characteristics
of
their
headaches
.
The
aims
of
this
study
were
to
determine
prevalence
and
characteristics
of
headaches
and
to
investigate
associations
between
headache
and
other
clinical
symptoms
or
brain
magnetic
resonance
imaging
(
MRI
)
findings
among
homogenous
group
of
patients
having
the
same
R
544
C
mutation
.
In
this
cross-sectional
study
,
we
enrolled
53
CADASIL
patients
with
the
R
544
C
mutation
between
May
2010
and
April
2011
.
We
obtained
the
history
of
headache
using
a
structured
questionnaire
and
detailed
interview
.
Other
clinical
features
and
brain
MRI
findings
were
also
assessed
for
potential
associations
.
Overall
headache
prevalence
was
45
.
3
%
(
24
patients
)
.
Among
them
,
21
patients
(
87
.
5
%
)
were
classified
as
having
tension-
type
headache
,
followed
by
migraine
(
two
patients
)
and
unclassifiable
headaches
(
one
patient
)
.
Except
for
alcohol
consumption
,
no
significant
associations
were
observed
between
the
headaches
and
other
clinical
features
or
brain
MRI
findings
.
Migraine
was
found
in
only
3
.
8
%
of
CADASIL
patients
with
the
R
544
C
mutation
.
Such
a
low
prevalence
of
migraine
may
hinder
clinical
detection
of
CADASIL
among
ethnically
Asian
patients
.