Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Is Alzheimer's disease a homogeneous disease entity?
[cadasil]
The
epidemic
proportions
of
dementia
in
old
age
are
a
cause
of
great
concern
for
the
medical
profession
and
the
society
at
large
.
It
is
customary
to
consider
Alzheimer
's
disease
(
AD
)
as
the
most
common
cause
of
dementia
,
and
vascular
dementia
(
VaD
)
as
being
the
second
.
This
dichotomous
view
of
a
primary
neurodegenerative
disease
as
opposed
to
a
disorder
where
extrinsic
factors
cause
brain
damage
led
to
separate
lines
of
research
in
these
two
entities
.
New
biomarkers
,
particularly
the
introduction
of
modern
neuroimaging
and
cerebrospinal
fluid
changes
,
have
,
in
recent
years
,
helped
to
identify
anatomical
and
chemical
changes
of
VaD
and
of
AD
.
Nevertheless
,
there
is
a
substantial
difference
between
the
two
entities
.
While
it
is
clear
that
VaD
is
a
heterogeneous
entity
,
AD
is
supposed
to
be
a
single
disorder
.
Nobody
attempts
to
use
CADASIL
as
a
template
to
develops
treatment
for
sporadic
VaD
.
On
the
other
hand
,
early
-onset
AD
is
used
to
develop
therapy
for
sporadic
AD
.
This
paper
will
discuss
the
problems
relating
to
this
false
concept
and
its
consequences
.
Diseases
Validation
Diseases presenting
"dementia"
symptom
adrenomyeloneuropathy
alexander disease
cadasil
canavan disease
carcinoma of the gallbladder
cushing syndrome
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
homocystinuria without methylmalonic aciduria
hydrocephalus with stenosis of the aqueduct of sylvius
inclusion body myositis
phenylketonuria
sneddon syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
