Rare Diseases Symptoms Automatic Extraction
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A random Abstract
Our Project
Our Team
Dementia in middle-aged patients with schizophrenia.
[cadasil]
Although
numerous
studies
have
assessed
cognitive
dysfunction
in
patients
with
schizophrenia
,
very
few
have
focused
on
the
diagnosis
of
dementia
.
Our
objectives
were
to
accurately
diagnose
dementia
in
a
cohort
of
middle
-aged
patients
with
schizophrenia
and
to
assess
the
type
of
dementia
.
96
patients
with
schizophrenia
(
46
inpatients
and
50
outpatients
)
,
aged
50
to
70
years
,
underwent
a
psychiatric
,
neurological
,
and
neuropsychological
evaluation
at
baseline
and
after
a
20
-
month
follow-up
.
We
established
a
3
-
step
procedure
:
1
)
diagnose
dementia
according
to
the
DSM
-IV
criteria
,
using
the
Mattis
Dementia
Rating
and
Activities
of
Daily
Living
scales
;
2
)
characterize
dementia
using
brain
imaging
,
perfusion
by
99
mTc-
ECD
-SPECT
and
laboratory
tests
including
Alzheimer
's
disease
cerebrospinal
fluid
biomarkers
;
and
3
)
search
for
genetic
determinants
.
Fourteen
patients
fulfilled
the
diagnostic
criteria
of
dementia
.
Four
were
diagnosed
with
possible
or
probable
behavioral
-variant
frontotemporal
dementia
(
bvFTD
)
,
two
with
probable
Alzheimer
's
disease
,
two
with
probable
vascular
dementia
(
including
one
due
to
CADASIL
)
,
one
with
CNS
inflammatory
disease
,
and
six
could
not
be
fully
characterized
.
The
diagnosis
of
dementia
in
middle
-aged
patients
with
schizophrenia
is
challenging
but
possible
,
using
a
multistep
procedure
.
The
most
frequent
condition
,
bvFTD
,
could
reflect
the
presence
of
an
evolutive
neurodegenerative
process
in
some
patients
.
Diseases
Validation
Diseases presenting
"schizophrenia"
symptom
22q11.2 deletion syndrome
achondroplasia
alexander disease
cadasil
child syndrome
congenital toxoplasmosis
kabuki syndrome
kallmann syndrome
krabbe disease
neuralgic amyotrophy
oligodontia
oral submucous fibrosis
zellweger syndrome
This symptom has already been validated