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A random Abstract
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Our Team
[Genetics of primary headache syndromes].
[cadasil]
Migraine
has
an
important
genetic
component
.
The
prototypic
monogenic
form
of
migraine
is
hemiplegic
migraine
,
a
rare
subtype
of
migraine
with
aura
,
for
which
three
causative
genes
have
been
identified
.
Studies
of
transgenic
animal
models
have
substantially
improved
our
understanding
of
the
molecular
pathophysiology
of
this
monogenic
model
disease
as
well
as
of
migraine
in
general
.
Beyond
this
,
there
are
other
(
rarer
)
monogenic
forms
of
migraine
,
e
.
g
.
,
in
the
context
of
hereditary
mostly
vascular
syndromes
such
as
CADASIL
.
By
contrast
,
the
common
types
of
migraine
with
and
without
aura
are
genetically
complex
.
With
the
identification
of
the
first
robust
genetic
risk
variants
in
large
genome-
wide
association
studies
,
our
knowledge
in
this
still
dynamically
expanding
field
has
substantially
increased
.
This
review
summarizes
the
current
status
of
migraine
genetics
,
with
a
special
focus
on
hemiplegic
migraine
as
well
as
the
most
recent
findings
in
complex
migraine
genetics
.
In
addition
,
the
first
preliminary
findings
on
the
genetics
of
other
types
of
primary
headache
disorders
(
cluster
headache
,
tension-
type
headache
)
are
briefly
reviewed
.
Diseases
Validation
Diseases presenting
"important genetic component"
symptom
cadasil
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