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Benign recurrent intrahepatic cholestasis. Some reflections on a case followed for 20 years.
[benign recurrent intrahepatic cholestasis]
Benign
recurrent
intrahepatic
cholestasis
(
BRIC
)
is
a
form
of
cholestasis
of
obscure
aetiology
characterized
by
recurrent
episodes
of
jaundice
and
itching
associated
with
a
morphological
picture
of
pure
intrahepatic
cholestasis
.
No
effective
treatment
has
yet
been
found
among
the
many
that
have
been
proposed
and
the
invariably
benign
nature
of
the
condition
has
been
questioned
.
A
case
of
BRIC
followed
for
a
period
of
20
years
is
described
.
This
case
is
of
great
interest
from
these
two
points
of
view
:
1
)
the
histologic
and
electron
microscopic
findings
23
and
41
years
after
the
first
episode
of
cholestasis
,
respectively
,
failed
to
reveal
evidence
of
the
possible
future
development
of
cirrhosis
;
2
)
treatment
with
ursodeoxycholic
acid
proved
ineffective
both
therapeutically
and
in
the
prevention
of
episodes
of
bile
stasis
:
on
the
contrary
,
calculosis
of
the
common
bile
duct
appeared
after
8
months
from
the
onset
of
the
treatment
.
