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Pruritus in chronic cholestatic liver disease.
[benign recurrent intrahepatic cholestasis]
Pruritus
is
a
troublesome
complication
in
patients
with
cholestatic
liver
disease
.
Several
links
to
its
pathogenesis
have
been
proposed
,
including
the
role
of
bile
acids
,
endogenous
opioid
and
serotonins
,
and
lysophosphatidic
acid
.
The
management
of
pruritus
in
cholestasis
is
challenging
.
Medical
treatment
of
the
underlying
cholestatic
condition
may
provide
benefit
.
Extracorporeal
albumin
dialysis
can
be
pursued
for
those
who
have
a
poor
quality
of
life
and
failed
the
various
therapeutic
interventions
,
while
awaiting
liver
transplantation
.
Experimental
interventions
,
and
the
management
of
pruritus
in
certain
conditions
such
as
intrahepatic
cholestasis
of
pregnancy
and
benign
recurrent
intrahepatic
cholestasis
,
are
also
briefly
reviewed
.
Diseases
Validation
Diseases presenting
"pruritus in certain conditions"
symptom
benign recurrent intrahepatic cholestasis
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