Treatment of pruritus with Prometheus dialysis and absorption system in a patient with benign recurrent intrahepatic cholestasis.

[benign recurrent intrahepatic cholestasis]

Benign recurrent intrahepatic cholestasis (BRIC ) is an autosomal recessive liver disorder characterized by recurrent episodes of jaundice and itching . Episodes of cholestasis last variously from 1 week to several months , may start at any age and usually resolve spontaneously . No effective treatment has been found as yet . We report a case of genetically proven BRIC in a male patient who developed three episodes of pruritus and jaundice at the age of 14 , 16 and 19 years . During the third episode , he did not respond to pharmacological medical therapy , and fractionated plasma separation and absorption (FPSA , Prometheus ) was performed to manage intractable pruritus . The treatment immediately alleviated pruritus , lowered serum bilirubin concentration and induced sustained remission in the 5 -year follow up . FPSA seems to be a safe and effective way of treatment for BRIC in patients with severe pruritus and prolonged jaundice .

Diseases
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Diseases presenting "severe pruritus" symptom

benign recurrent intrahepatic cholestasis

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